This special issue will focus on the computational methods and models employed to study immune system functioning under health and disease conditions.
Papers discussing computational models, at any level of description (e.g., microscopic/intracellular, mesoscopic/intercellular, macroscopic/tissue or organs), along with their application in understanding the pathogenesis of specific diseases (e.g., infectious diseases, cancers, hypersensitivities, autoimmune disorders), are all welcome.
Topics of interest include, but are not limited to:
• modeling techniques (agent vs. equation based, continuous vs. discrete, bioinformatics, network studies);
• spatially-extended models (e.g., models of lymph channels and/or lymph nodes);
• models of cell homing in (and trafficking among) lymph nodes;
• computational applications to diseases, in silico testing and optimization of therapeutic/vaccination regimes;
• models encompassing two or more spatial or temporal scales (e.g., from cell functions to organs);
• computational methods of network analysis.
The computation aspect of these models should be posed in evidence, as it often constitutes a limiting factor (e.g., in the development of micro-simulation models). Moreover, methods addressing the issue of parameter estimation and the fast exploration of large parameter spaces, as well as the analysis of experimental data, are considered important in the field.
Research papers, reviews, and short communications on all topics related to the above issues are invited.
Deadline for manuscript submissions: 31 January 2015
Dr. Filippo Castiglione
Dr. Paolo Tieri