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Non Fickian drug release from polymeric matrices: mathematical modelling and numerical simulation

2014-09-03

Jose Ferreira, Department of Mathematics, University of Coimbra, Portugal

Abstract: 
Polymer release systems involve an anomalous diffusive desorption which cannot be completely explained by Fickian models, as shown by experiments.   In recent years some attempts have been made to model mathematically such behaviors. Three main phenomena are identified in the drug release: the penetrant uptake, the drug dissolution and the drug diffusion, which dependent on viscoelastic properties of the polymeric matrix and   drug properties. The non-Fickian character of the diffusion is simulated by considering that there is a non local dependence of the dynamics upon the configuration.
In this talk we are focused mainly in the mathematical modelling and numerical simulation of drug release from polymeric matrices in different scenarios.

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