Sobolev inequalities in the whole of R^n

A comprehensive approach to Sobolev-type embeddings, involving arbitrary rearrangement- invariant norms on the entire Euclidean space R^n, is offered. In particular, the optimal target space in any such embedding is exhibited. Crucial in our analysis is a new reduction principle for the relevant embeddings, showing their equivalence to a couple of considerably simpler one-dimensional inequalities. Applications to the classes of the Orlicz-Sobolev and the Lorentz-Sobolev spaces are also presented. These contributions fill in a gap in the existing literature, where sharp results in such a general setting are only available for domains of finite measure.