This contribution outlines current research aimed at developing models for personalized type 2 diabetes mellitus (T2D) prevention in the framework of the European project PRAESIIDIUM (Physics Informed Machine Learn-ing-Based Prediction and Reversion of Impaired Fasting Glucose Management) aimed at building a digital twin for preventing T2D in patients at risk.

In this work, we propose and explore a novel network-constraint survival methodology considering the Weibull accelerated failure time (AFT) model combined with a penalized likelihood approach for variable selection and estimation [2]. Our estimator explicitly incorporates the correlation patterns among predictors using a double penalty that promotes both sparsity and the grouping effect. In or- der to solve the structured sparse regression problems we present an efficient iterative computational algorithm based on proximal gradient descent method [1].

Understanding brain function from magneto-electroencephalographic (M/EEG) measurements requires advanced mathematical and signal processing tools. Although the analysis of M/EEG data at sensors level sheds light on important brain mechanisms, full exploitation of the information contained in such brain data could be achieved by reconstructing the active neural sources from M/EEG measurements.

This article is concerned with the rigorous justification of the hydrostatic limit for continuously stratified incompressible fluids under the influence of gravity. The main peculiarity of this work with respect to previous studies is that no (regularizing) viscosity contribution is added to the fluid-dynamics equations and only diffusivity effects are included.

Background: The oral food challenge test (OFC) represents the gold standard for the diagnosis of food allergy (FA). It is also necessary for the safe reintroduction of the allergen into the diet of the patient. However, it is burdened with serious side effects.