Aggregating transcriptomics data across hospitals can increase sensitivity and robustness of differential expression analyses, yielding deeper clinical insights. As data exchange is often restricted by privacy legislation, meta-analyses are frequently employed to pool local results. However, the accuracy might drop if class labels are inhomogeneously distributed among cohorts. Flimma (https://exbio.wzw.tum.de/flimma/) addresses this issue by implementing the state-of-the-art workflow limma voom in a federated manner, i.e., patient data never leaves its source site.

The paper deals with a special filtered approximation method, which originates interpolation polynomials at Chebyshev zeros by using de la Vallée Poussin filters. In order to get an optimal approximation in spaces of locally continuous functions equipped with weighted uniform norms, the related Lebesgue constants have to be uniformly bounded. In previous works this has already been proved under different sufficient conditions. Here, we complete the study by stating also the necessary conditions to get it.

Presentazione orale al side event - GEO Week 2018 - Sede: Kyoto (JP) - La GEO WEEK è la conferenza scientifica internazionale di GEO che precede il summit annuale dei 200 membri di GEO. Si tiene alternativamente in America, Asia, Europa, Africa e Oceania.

In this paper we propose and study a hybrid discrete-continuous mathematical model of collective motion under alignment and chemotaxis effect. Starting from paper [23], in which the Cucker-Smale model [22] was coupled with other cell mechanisms, to describe the cell migration and self-organization in the zebrafish lateral line primordium, we introduce a simplified model in which the coupling between an alignment and chemotaxis mechanism acts on a system of interacting particles.

The dynamic interaction of complex fluid interfaces is highly sensitive to near-contact interactions occurring at the scale of ten of nanometers. Such interactions are difficult to analyze because they couple self-consistently to the dynamic morphology of the evolving interface, as well as to the hydrodynamics of the interstitial fluid film.

We present a mesoscale kinetic model for multicomponent flows, augmented with a short range forcing term, aimed at describing the combined effect of surface tension and near-contact interactions operating at the fluid interface level. Such a mesoscale approach is shown to (i) accurately capture the complex dynamics of bouncing colliding droplets for different values of the main governing parameters, (ii) predict quantitatively the effective viscosity of dense emulsions in micro-channels and (iii) simulate the formation of the so-called soft flowing crystals in microfluidic focusers.

Parties of reputation systems rate each other and use ratings to compute reputation scores that drive their interactions. When deciding which reputation model to deploy in a network environment, it is important to find the most suitable model and to determine its right initial configuration. This calls for an engineering approach for describing, implementing and evaluating reputation systems while taking into account specific aspects of both the reputation systems and the networked environment where they will run.

Trust and reputation systems are decision support tools used to drive parties' interactions on the basis of parties' reputation. In such systems, parties rate with each other after each interaction.

The integral representation of some biological phenomena consists in Volterra equations whose kernels involve a convolution term plus a non convolution one. Some significative applications arise in linearised models of cell migration and collective motion, as described in Di Costanzo et al. (Discrete Contin. Dyn. Syst. Ser. B 25 (2020) 443-472), Etchegaray et al. (Integral Methods in Science and Engineering (2015)), Grec et al. (J. Theor. Biol. 452 (2018) 35-46) where the asymptotic behaviour of the analytical solution has been extensively investigated.

In some important biological phenomena Volterra integral and integrodifferential equations represent an appropriate mathematical model for the description of the dynamics involved (see e.g. [1], and the bibliography therein).