MODELING AND SIMULATION OF INDIVIDUALS BEHAVIOUR ON BIOLOGICAL NETWORKS

Here we present some studies on the behavior of individuals in a biological networks. The first study is about Physarum polycephalum slime mold and its ability to find the shortest path in a maze. Here we present a PDE chemotaxis model that reproduce its behavior in a network, schematized as a planar graph, (1). In particular, suitable transmission and boundary conditions at each node of the graph are considered to mimic the choice of such an organism to move from an arc to another arc of the network, motivated by the search for food.

Designing a Network Proximity-Based Drug Repurposing Strategy for COVID-19

The ongoing COVID-19 pandemic still requires fast and effective efforts from all fronts, including epidemiology, clinical practice, molecular medicine, and pharmacology. A comprehensive molecular framework of the disease is needed to better understand its pathological mechanisms, and to design successful treatments able to slow down and stop the impressive pace of the outbreak and harsh clinical symptomatology, possibly via the use of readily available, off-the-shelf drugs.

The epigenetics of inflammaging: The contribution of age-related heterochromatin loss and locus-specific remodelling and the modulation by environmental stimuli

A growing amount of evidences indicates that inflammaging - the chronic, low grade inflammation state characteristic of the elderly - is the result of genetic as well as environmental or stochastic factors. Some of these, such as the accumulation of senescent cells that are persistent during aging or accompany its progression, seem to be sufficient to initiate the aging process and to fuel it. Others, like exposure to environmental compounds or infections, are temporary and resolve within a (relatively) short time.

Analysis of a model for waterborne diseases with Allee effect on bacteria

A limitation of current modeling studies in waterborne diseases (one of the leading causes of death worldwide) is that the intrinsic dynamics of the pathogens is poorly addressed, leading to incomplete, and often, inadequate understanding of the pathogen evolution and its impact on disease transmission and spread. To overcome these limitations, in this paper, we consider an ODEs model with bacterial growth inducing Allee effect. We adopt an adequate functional response to significantly express the shape of indirect transmission.

Bounds in Total Variation Distance for Discrete-time Processes on the Sequence Space

Let P and (P) over tilde be the laws of two discrete-time stochastic processes defined on the sequence space S-N,where S is a finite set of points. In this paper we derive a bound on the total variation distance d(TV)(P, (P) over tilde) in terms of the cylindrical projections of P and (P) over tilde. We apply the result to Markov chains with finite state space and random walks on Z with not necessarily independent increments, and we consider several examples.

Models of polymer solutions in electrified jets and solution blowing

Fluid flows hosting electrical phenomena are the subject of a fascinating and highly interdisciplinary scientific field. In recent years, the extraordinary success of electrospinning and solution-blowing technologies for the generation of polymer nanofibers has motivated vibrant research aiming at rationalizing the behavior of viscoelastic jets under applied electric fields or other stretching fields including gas streams.

Multiparticle collision dynamics for fluid interfaces with near-contact interactions

We present an extension of the multiparticle collision dynamics method for flows with complex interfaces, including supramolecular near-contact interactions mimicking the effect of surfactants. The new method is demonstrated for the case of (i) short range repulsion of droplets in close contact, (ii) arrested phase separation, and (iii) different pattern formation during spinodal decomposition of binary mixtures.

A regularization model for stereo vision with controlled continuity

The problem of the computation of stereo disparity is approaehed as a mathematically ill-posed problem by using regularization theory. A controlled continuity constraint which provides a local spatial control over the smoothness of the solution enables the problem to be regularized while preserving the disparity discontinuities. The discontinuities are localized during the regularization process by examining the size of the disparity gradient at the gray value edges.