Mathematical model for transport of DNA plasmids from the external medium up to the nucleus by electroporation

We propose a mathematical model for the transport of DNA plasmids from the extracellular matrix up to the cell nucleus. The model couples two phenomena: the electroporation process, describing the cell membrane permeabilization to plasmids and the intracellular transport enhanced by the presence of microtubules. Numerical simulations of cells with arbitrary geometry, in 2D and 3D, and a network of microtubules show numerically the importance of the microtubules and the electroporation on the effectiveness of the DNA transfection, as observed by previous biological data.

Tra ricerca scientifica e divulgazione : un nuovo ruolo per le biblioteche degli enti di ricerca

L’articolo mette in evidenza come lo sviluppo culturale e civile di un paese sia strettamente collegato con il progresso della sua struttura socioeconomica e, contemporaneamente, con il livello generale di produzione e diffusione delle conoscenze scientifiche nei diversi strati sociali, dando risalto al ruolo che il bibliotecario degli istituti di ricerca, in qualità di operatore attivo nella produzione scientifica ed esperto dei sistemi informativi, può giocare.

DSMC-LBM mapping scheme for rarefied and non-rarefied gas flows

We present the formulation of a kinetic mapping scheme between the Direct Simulation Monte Carlo (DSMC) and the Lattice Boltzmann Method (LBM) which is at the basis of the hybrid model used to couple the two methods in view of efficiently and accurately simulate isothermal flows characterized by variable rarefaction effects. Owing to the kinetic nature of the LBM, the procedure we propose ensures to accurately couple DSMC and LBM at a larger Kn number than usually done in traditional hybrid DSMC--Navier-Stokes equation models.

OpenCAPWAP v2.0: the new open-source implementation of the CAPWAP protocol

We present the latest version of OpenCAPWAP, our open-source implementation of the Internet Engineering Task Force control and provisioning of wireless access point (CAPWAP) protocol. The CAPWAP protocol is designed to support centralized management of large-scale and heterogeneous wireless networks, with a special focus on IEEE 802.11-based networks. The implementation presented in this paper improves substantially on the previous version, adding full support for the Split MAC architecture and decoupling completely the implementation from a specific driver solution.

Numerical approximation of nonhomogeneous boundary conditions on networks for a hyperbolic system of chemotaxis modeling the Physarum dynamics

Many studies have shown that Physarum polycephalum slime mold is able to find the shortest path in a maze. In this paper we study this behavior in a network, using a hyperbolic model of chemotaxis. Suitable transmission and boundary conditions at each node are considered to mimic the behavior of such an organism in the feeding process. Several numerical tests are presented for special network geometries to show the qualitative agreement between our model and the observed behavior of the mold.